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Identifying essential, asthma-specific upstream receptors or adaptor proteins, such as sprouty-2, that provide a more limited treatment window is another approach

This process is accompanied by the ETC breakdown with the failure to produce the necessary amount of ATP, uncompensated production of ROS and RNS, and breakdown of various molecules, which leads to the loss of mitochondrial and cell integrity, and activation of programmed cell death and necrosis

Together they cover four receptor pathways

These dendrimers offer advantages such as high drug-loading capacity, improved aqueous solubility, and sustained release